Type | Deposited Protein | Clinical Associations |
Systemic | Immunoglobulin lambda chains | Multiple myeloma |
Transthyretin | Familial amyloidosis, senile cardiac amyloidosis | |
Amyloidosis – A protein | Inflammation-associated amyloidosis | |
Beta2 -microglobulin | Dialysis-related amyloidosis | |
Immunoglobulin heavy chains | Systemic amyloidosis | |
Hereditary | Fibrinogen alpha chain, Apo A1 and Apo A2 | Familial systemic amyloidosis |
Lysozyme | Familial systemic amyloidosis | |
Central nervous system | Beta protein precursor | Alzheimer's |
Prion protein | Creutzfeldt-Jakob disease, Gerstmann-Strãussler-Scheinker disease, fatal familial insomnia | |
Cystatin C | hereditary cerebral hemorrhage with amyloidosis (Icelandic) | |
Ocular | Gelsolin | Familial amyloidosis (Finnish) |
Lactoferrin | Familial corneal amyloidosis | |
Keratoepithelin | Familial corneal dystrophies | |
Localized | Calcitonin | Thyroid Carcinoma (Medullary) |
Amylin | Insulinoma, type 2 diabetes | |
Atrial natriuretic factor amyloid | Isolated atrial amyloidosis | |
Prolactin | Pituitary amyloid | |
Keratin | Cutaneous amyloidosis | |
Medin | Aortic amyloidosis in elderly people |
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Primary Amyloidosis- Types, proteins and clinical associations
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