Primary Amyloidosis- Types, proteins and clinical associations





Type Deposited Protein Clinical Associations
Systemic Immunoglobulin lambda chains Multiple myeloma
Transthyretin Familial amyloidosis, senile cardiac amyloidosis
Amyloidosis – A protein Inflammation-associated amyloidosis
Beta2 -microglobulin Dialysis-related amyloidosis
Immunoglobulin heavy chains Systemic amyloidosis
Hereditary Fibrinogen alpha chain, Apo A1 and Apo A2 Familial systemic amyloidosis
Lysozyme Familial systemic amyloidosis
Central nervous system Beta protein precursor Alzheimer's
Prion protein Creutzfeldt-Jakob disease, Gerstmann-Strãussler-Scheinker disease, fatal familial insomnia
Cystatin C hereditary cerebral hemorrhage with amyloidosis (Icelandic)
Ocular Gelsolin Familial amyloidosis (Finnish)
Lactoferrin Familial corneal amyloidosis
Keratoepithelin Familial corneal dystrophies
Localized Calcitonin Thyroid Carcinoma (Medullary)
Amylin Insulinoma, type 2 diabetes
Atrial natriuretic factor amyloid Isolated atrial amyloidosis
Prolactin Pituitary amyloid
Keratin Cutaneous amyloidosis
Medin Aortic amyloidosis in elderly people

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