Common paraneoplastic syndromes

Paraneoplastic Limbic Encephalitis : 

PLE is characterized by irritability, seizures, short-term memory loss and depression. MRI reveals bilateral mesial temporal lobe hyperintensities on T2 weighted images. Small cell lung carcinoma is the most common associated cancer. 

Paraneoplastic Cerebellar Degeneration :

PCD patients present with cerebellar signs. MRI may be normal in initial stages. Common malignancies associated with this syndrome include -Small cell lung cancer, ovarian cancer, breast cancer and Hodgkin's lymphoma. 

Paraneoplastic Encephalomyelitis : 

In this condition there is patchy inflammation involving multiple areas of the nervous system. The tumor most frequently involved is again Small Cell Lung Carcinoma. 

Paraneoplastic Sensory Neuropathy : 

It is usually sensory neuropathy.  

Opsoclonus-myoclonus :

This syndrome usually affects young children. While 50% of children with this syndrome have neuroblastoma only about 2% of children with this tumor develop opsoclonus.  

Lambert-Eaton Myasthenic Syndrome (LEMS): 

This is a Neuromuscular junction disorder characterized by Acetylcholine release problems from the presynaptic terminal.Symptoms are similar to myasthenia gravis. Diagnosis is often made using EMG. LEMS results from immunologic attack against the presynaptic terminal that cause interference with the release of Acetylcholine.