Commonest cause of raised MSAFP = mistaken dates.
Triple screen for antenatal diagnosis of Down's syndrome uses MSAFP, Unconjugated estriol (both are decreased in Down's) and Serum beta HCG (Increased in Down's).
All 3 are decreased in Trisomy 18.
Also remember
Chorionic villus sampling = earliest by 10-12 weeks gestation.
Amniocentesis = earliest by 14-16 weeks gestation.
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