Characteristic symptoms of AS include back pain that is worst in the morning and improves with exercise. AS is more common in men, and patients usually present at a younger age (18-35 years) relative to patients with mechanical causes of back pain or arthritis.
AS is a clinical diagnosis, HLA B27 testing is positive in a large proportion of patients with AS but one should keep in mind that in the general population, about 8% Caucasian, 4% African, 2-9% Chinese, and 0.1-0.5% Japanese have the HLA-B27 antigen.
Commonest cause of death related to AS is renal failure secondary to amyloidosis in AS.
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