Rasburicase is used in the management of Tumor Lysis Syndrome. It is an enzyme called urate-oxidase. It is naturally present in many animals but not in humans. Rasburicase catalyses the conversion of uric acid to allantoin. Allantoin is an inactive metabolite of purine metabolism, and is 5 to 10 times more soluble than uric acid, so renal excretion is more effective.
Contraindications: Pregnancy, G6PD deficiency.
No comments:
Post a Comment
Thank you for your time.